50-18-0 MSDS - Cyclophosphamide
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Cyclophosphamide

Identification
Name Cyclophosphamide
CAS Registry Number 50-18-0
Synonyms (Bis(chloro-2-ethyl)amino)-2-tetrahydro-3,4,5,6-oxazaphosphorine-1,3,2-oxide-2 hydrate;2-(Bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorine 2-oxide;2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-, 2-oxide;2-H-1,3,2-Oxazaphosphorinane;2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-,2-oxide;2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)tetrahydro-,2-oxide, monohydrate;ASTA;Asta B 518
Molecular Structure Cyclophosphamide   50-18-0
Molecular Formula C7H15Cl2N2O2P
Molecular Weight 261.085961
mp: 41-45℃
Safety Statements: 22-24/25
RIDADR: UN 1851
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
50-18-0.pdf
Cyclophosphamide
Cyclophosphamide.svg
R-cyclophosphamide-from-xtal-1996-3D-balls.png
Clinical data
Pronunciation /ˌsklˈfɒsfəˌmd, -lə-/[1][2]
Trade names Lyophilized Cytoxan, Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cycloblastin
AHFS/Drugs.com Monograph
MedlinePlus a682080
Pregnancy
category
  • AU: D
  • US: D (Evidence of risk)
Routes of
administration
by mouth, intravenous
ATC code
  • L01AA01 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability >75% (by mouth)
Protein binding >60%
Metabolism Liver
Biological half-life 3–12 hours
Excretion Kidney
Identifiers
CAS Number
  • 50-18-0 YesY
PubChem CID
  • 2907
DrugBank
  • DB00531 YesY
ChemSpider
  • 2804 YesY
UNII
  • 6UXW23996M
KEGG
  • D07760 YesY
ChEBI
  • CHEBI:4027 YesY
ChEMBL
  • CHEMBL88 YesY
ECHA InfoCard 100.000.015
Chemical and physical data
Formula C7H15Cl2N2O2P
Molar mass 261.086 g/mol
3D model (JSmol)
  • Interactive image
Melting point 2 °C (36 °F)
  (verify)

Cyclophosphamide (CP), also known as cytophosphane among other,[3] is a medication used as chemotherapy and to suppress the immune system.[4] As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma.[4] As an immune suppressor it is used in nephrotic syndrome and following organ transplant.[4] It is taken by mouth or injection into a vein.[4]

Most people develop side effects.[4] Common side effects include low white blood cell counts, loss of appetite, vomiting, hair loss, and bleeding from the bladder.[4] Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis.[4] Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications.[4] It is believed to work by interfering with the duplication of DNA and the creation of RNA.[4]

Cyclophosphamide was approved for medical use in the United States in 1959.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] The wholesale cost in the developing world is about 3.65 to 14.30 USD per 1 g vial.[6] In the United Kingdom this dose costs the NHS about 17.06 pounds.[7] In the United States this dose by mouth is about 19.56 USD.[8]


 







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